Wakix (pitolisant) is also approved to treat excessive daytime sleepiness (EDS) and cataplexy associated with narcolepsy. There is also a newer version of Xyrem called Xywav, which is specifically designed to have a lower sodium content - which is helpful for people with salt-sensitive high blood pressure. It is not well understood how Xyrem works to treat cataplexy. Xyrem is available only through a restricted-access enrollment program. Another form of sodium oxybate, gamma hydroxybutyrate (GHB), is abused recreationally by some people. Common side effects of Xyrem can include confusion, dizziness, and headaches. Sodium oxybate, the active ingredient in Xyrem, is a substance that occurs naturally in the brain and is involved with sleep regulation. It is also approved to treat excessive daytime sleepiness associated with narcolepsy. Xyrem (sodium oxybate) is currently the only drug approved to treat type 1 narcolepsy (specifically indicated as cataplexy associated with narcolepsy). Most drugs approved for treating narcolepsy are scheduled by the government as controlled substances due to their potential for abuse.
All of the drugs described below are taken orally. Food and Drug Administration treat narcolepsy based on the type or major symptoms.
FDA-Approved Medicationsĭrugs approved by the U.S. Off-label means that the drugs have not been approved for treating narcolepsy.
Food and Drug Administration (FDA) specifically to treat narcolepsy, while others may be prescribed to treat narcolepsy off-label. Many medications may be prescribed to treat narcolepsy. Treatment for narcolepsy is most often a combination of medication and lifestyle changes that promote good sleep hygiene.
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